Test Of The Effectiveness Of Gingier Extract (Zingiber officinale) As An Antirheumatist Against Mice (Mus muscullus)

Abstract

Background Rheumatism is an autoimmune disease characterized by joint inflammation, pain, and swelling that reduces patients' quality of life. Modern therapies such as NSAIDs and corticosteroids are effective but may cause serious side effects with long-term use. Ginger (Zingiber officinale) contains bioactive compounds such as gingerol, shogaol, and paradol with anti-inflammatory and analgesic properties, making it a potential herbal alternative for anti-rheumatic therapy. Objective : This study aimed to evaluate the effectiveness of ginger extract as an anti-rheumatic agent in male white mice (Mus musculus) induced with carrageenan. Methods This experimental laboratory study used 15 mice divided into five groups: negative control (0.5% Na CMC), positive control (sodium diclofenac), and three treatment groups with ginger extract doses of 200 mg/kg BW, 400 mg/kg BW, and 800 mg/kg BW. The main parameter was the reduction of paw edema measured with calipers every 60 minutes for 360 minutes. Data were analyzed using ANOVA. Results Ginger extract at 800 mg/kg BW showed the most significant reduction of edema, comparable to sodium diclofenac. The 200 mg/kg BW dose produced the lowest effect. ANOVA results indicated significant differences between groups (p < 0.05). Conclusion Ginger extract demonstrated effective anti-rheumatic activity, with the optimal dose at 800 mg/kg BW. Ginger has strong potential to be developed as a safe and effective herbal therapy for rheumatism.